The Human Upgrade with Dave Asprey

What if you could cheat aging, indulge in life’s guilty pleasures, and still thrive? Dr. Sandra Kaufmann, a pioneering longevity expert and fearless explorer of the biochemical frontier, joins Dave to reveal how you can bend the rules of biology to live longer, smarter, and stronger. Forget perfection—Dr. Kaufmann’s radically practical approach embraces the human side of longevity, showing you how to optimize your body while enjoying the ride. From downing Diet Cokes to defying traditional medical dogma, she’s rewritten the playbook on anti-aging with her Seven Tenets of Aging. Together, she and Dave dive into everything from molecular hacks for outsmarting junk food to unlocking the secret power of your mitochondria, DNA, and circadian rhythms. This episode goes beyond the surface with mind-blowing insights, hilarious moments, and actionable steps to take your health (and your fun) to the next level. What You’ll Learn: • The Seven Tenets of Aging and how they’ll change your approach to health • Why indulging in “bad” habits doesn’t have to sabotage your longevity • Biochemical secrets to combat oxidative stress, glycation, and cellular junk • The real story behind NAD, circadian rhythms, and the tools for better sleep • How to create a personalized health plan that’s sustainable, effective—and fun Resources: • Supplement Protocol One-Sheet for this episode: https://www.instagram.com/dave.asprey/?hl=en• 2025 Biohacking Conference: https://biohackingconference.com/2025 • Kaufmann Protocol Website: https://kaufmannprotocol.com • Sandra Kaufmann’s Book – Why We Age and How to Stop It: https://www.amazon.com/Kaufmann-Protocol-Why-Age-Stop/dp/0692089047 • Sandra Kaufmann’s Instagram: https://www.instagram.com/kaufmannantiaging/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: Leela Quantum | Head to https://leelaq.com/DAVE for 10% off. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Timestamps: • 00:00 Trailer • 00:45 Guest Introduction • 02:30 Longevity Insights • 04:22 Personal Stories • 08:00 Pharmaceuticals • 12:26 Diet and Lifestyle • 18:19 Seven Tenets • 22:04 Sleep and Circadian Rhythms • 26:41 NAD and Supplements • 37:46 Blood Sugar and AGEs • 47:09 Microcirculation • 49:08 NRS and Imports • 49:18 Celebrex Medication • 50:03 Celebrex Benefits • 50:41 Alzheimer’s and Celebrex • 51:28 Antioxidants • 54:26 Stem Cells and Exosomes • 58:03 Laser Skin Treatments • 01:07:34 Hormones and Longevity • 01:20:03 Lithium for Mood • 01:27:45 Gender and Longevity • 01:32:39 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is there actual “magic” on this planet, or is it just in the movies? Dr. Barry Morguelan, a top surgeon and one of only nine living grandmasters of an ancient Lao Tzu lineage, joins Dave to share secrets that have been hidden for 5,000 years. Together, they explore how the principles behind quantum physics, energy mastery, and timeless healing techniques can revolutionize your health, mindset, and life. From breaking rocks with energy to healing broken bones with focused intent, Dr. Barry reveals the extraordinary power of the “Great 8” — a framework to unlock your potential in relationships, creativity, health, intelligence, and more. This episode is packed with incredible stories, actionable wisdom, and a secret GIFT to help you start your own journey toward unparalleled vitality and longevity! What You’ll Learn: • The 8 ancient secrets to mastering energy, healing, and peak performance • How you can harness quantum physics for success • Why energy techniques can REVERSE aging and boost health naturally • The science of serendipity and how you can harness it daily • How to grow stronger, smarter, and healthier every day with simple practices Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Follow Dr. Barry on Instagram: https://www.instagram.com/energyforsuccess.official?igsh=eGcwZWhid3Q1M2Rm&utm_source=qr• Explore the Great 8 and Get Your Free Gift: https://energyforsuccess.com/dave/ • Learn More About Energy Practices: https://energyforsuccess.com/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: - Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. - Calroy | Head to https://calroy.com/dave for an exclusive discount. Timestamps: • 00:00 Trailer • 01:10 Introduction to Dr. Barry and His Journey • 06:16 The Turning Point: Mrs. Rodriguez’s Story • 09:04 Exploring Alternative Medicine Around the World • 13:02 Discovering Ancient Chinese Healing Techniques • 16:39 The Power of Quantum Physics and Lao Tzu’s Teachings • 27:25 Personal Experiences with Energy Healing • 36:35 The Great Eight: Structuring Your Day for Success • 36:51 Introduction to Energy for Success • 37:17 Understanding the Great Eight • 38:23 The Matrix and Animal Brain • 44:39 The Importance of Serendipity • 49:35 Four Categories of People • 53:02 Personal Experiences and Lessons • 58:34 The Power of Energy Practices • 01:07:06 Conclusion and Call to Action See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What happens when nearly 60 years of combined biohacking expertise collide in one podcast? Peter Diamandis is a world-renowned futurist, space entrepreneur, and innovator behind groundbreaking ventures like the XPRIZE and Abundance 360. Dave sits down with Peter to combine their nearly 60 years of biohacking expertise, delivering the ultimate playbook for living longer and healthier.They dive into revolutionary AI-driven health solutions, mindset shifts that fuel vitality, and practical routines you can start today. Peter, the author of The Longevity Guidebook, shares deeply meaningful tools and tips to expand your healthspan for decades to come. What You’ll Learn: • The top AI tools reshaping health and longevity • Simple daily habits that improve energy, sleep, and brain performance • Why mindset is the key to adding years to your life • The cutting-edge science of age reversal and functional health • How Peter and Dave biohack their routines for peak performance Resources: • 2025 Biohacking Conference: https://biohackingconference.com/2025 • Peter Diamandis’s New Book: https://longevityguidebook.com/home-blk-nav • Peter Diamandis’s Website: https://www.diamandis.com/ • Peter Diamandis’s Purpose Finder (MTP): https://purposefinder.ai/ • Danger Coffee: https://dangercoffee.com • Dave Asprey’s Website: https://daveasprey.com • Dave Asprey’s Book – Smarter Not Harder: https://daveasprey.com/books • Dave Asprey’s Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com SPONSORS: -Omni-Biotic | Visit omnibioticlife.com/dave and use code DAVE20 for 20% off. -LMNT | Free LMNT Sample Pack with any drink mix purchase by going to drinklmnt.com/dave. Timestamps: • 00:00 Open • 00:53 Introduction to Peter Diamandis • 01:54 Peter’s Longevity Journey • 03:26 Tracking Sleep and Biohacking • 05:49 The Importance of Deep Sleep • 07:22 Thinking Big and Longevity • 10:36 Russian Innovations in Sleep • 25:29 AI and Longevity • 29:01 Gene Editing and Epigenetics • 35:13 Light Therapy and Routines • 43:07 Gut Health and Endotoxins • 44:17 Exploring Conscious Pain Practices • 45:51 Hacking Hot Tubs for Health Benefits • 46:28 The Science Behind Dopamine Reset • 46:43 Introduction to Fountain Life • 48:41 Advanced Diagnostics and AI Integration • 50:29 Therapeutics and Cutting-Edge Treatments • 51:41 The Evolution of Longevity Companies • 55:30 The Future of Longevity and Healthspan • 01:01:27 The Role of AI in Health and Longevity • 01:07:31 Personal Longevity Practices and Insights • 01:16:43 Finding Your Purpose for Longevity • 01:24:01 Final Thoughts and Resources See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could ditch your glasses forever by simply doing a 10-minute exercise each day? In this episode, Dave sits down with Dr. Bryce Appelbaum, a visionary in vision biohacking, to uncover how simple techniques can transform your eyesight. From near-far focusing to eye stretches, these exercises don’t just improve your vision—they enhance your brain’s performance, energy, and overall health. Dr. Bryce shares his own journey of overcoming severe vision challenges, the science behind vision training, and how anyone can rewire their brain for sharper sight. If you’re dealing with nearsightedness, eye strain, or just want to keep your eyes sharp as you age, this episode shares simple ways to improve how you see the world—literally! What You’ll Learn: • Why vision training is the next frontier in biohacking • Three free techniques to improve your vision naturally • How your eyesight affects brain performance and energy levels • Why kids and adults need to get outside for better eye health • How to train your eyes to stop relying on glasses Go to www.screenfit.com/enroll and use code DAVE ($200 OFF with the code) Or Visit myvisionfirst.com/dave/ for 5000$ off the premium concierge program! SponsorsZbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order.Resources: • 2025 Biohacking Conference – https://biohackingconference.com/2025 • Screenfit- Visit https://www.screenfit.com/enroll and use code DAVE ($200 OFF with the code, from $497 to $297) • MyVisionFirst – Visit https://myvisionfirst.com/dave/ and apply now to get $5000 off • Danger Coffee – https://dangercoffee.com • Dave Asprey’s Website – https://daveasprey.com • Dave Asprey’s Book: Smarter Not Harder – https://daveasprey.com/books • Dave Asprey’s Linktree – https://linktr.ee/daveasprey • Upgrade Collective: Join The Human Upgrade Podcast Live – https://www.ourupgradecollective.com • Own an Upgrade Labs – https://ownanupgradelabs.com • Upgrade Labs – https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement – https://40yearsofzen.com Timestamps: • 00:00 Intro • 00:29 Dave Asprey’s Vision Journey • 04:33 Understanding Vision Beyond 20/20 • 08:01 Impact of Environment on Vision • 22:47 Exercises to Improve Vision • 27:29 Effective Eye Exercises for Better Vision • 27:46 Daily Routine for Eye Health • 29:12 Peripheral Vision Training • 31:15 Vision and Body Connection • 33:38 Handling Visual Overload • 35:04 Vision Training Benefits • 39:25 Neuroplasticity and Vision • 45:22 Vision Training for All Ages • 46:38 Practical Vision Improvement Tips • 54:24 Final Thoughts on Vision Training See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.