A Nobel Prize For Chemistry Work ‘Totally Separate From Biology’
In 2022, the Nobel Prize in Chemistry went to Dr. Carolyn Bertozzi of Stanford University, Dr. Morten Meldal of the University of Copenhagen, and Dr. K. Barry Sharpless of the Scripps Research Institute “for the development of click chemistry and bioorthogonal chemistry.” In “click chemistry,” molecular building blocks snap together quickly and efficiently to let chemists build more complicated molecules. But bioorthogonal chemistry takes that work one step further, allowing the technique to be used within living organisms without damaging cells.“When someone is thinking outside the box, or in a very different way, we like to think of that as orthogonal thinking,” Bertozzi explained. “So biorthogonal means not interacting with biology. Totally separate from biology.” Her research began with an interest in developing ways to see specific sugar molecules on the surface of cells. But it has developed into an approach that can be used for advanced drug delivery in fields such as chemotherapy.As part of Science Friday’s 33rd anniversary show, we’re revisiting our listeners’ favorite stories, including this one. In 2022, Bertozzi joined Ira Flatow for a wide-ranging conversation about her research, chemistry education, her early music career, and the importance of diversity in the field of chemistry.Transcripts for each segment will be available after the show airs on sciencefriday.com.
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Alan Alda Reflects On Life With Parkinson’s
In 2018, actor, author and science communicator Alan Alda spoke publicly about his diagnosis for Parkinson’s Disease. Alda, who is best known for his role in “M*A*S*H,” “The Aviator,” and “The West Wing,” shifted his interests to science communication in his later years. He’s written several books on the topic, and has an ongoing podcast, “Clear + Vivid.”As part of Science Friday’s 33rd anniversary show, we’re revisiting our listeners’ favorite stories, including this one. Alda came on Science Friday in 2018 to talk about his life since his Parkinson’s diagnosis, and how being an advocate for science changes his perspective on his condition. Transcripts for each segment will be available after the show airs on sciencefriday.com.
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A Horn Of Potato Plenty | Adding Marbling To Fake Meat For An Extra-Realistic Bite
Just in time for Thanksgiving, a potato researcher explains potato varieties, potato nutrition, and some tubular tuber facts. And, irregular, fatty marbling gives meat a unique texture. Recreating that in plant-based products isn’t easy.A Horn Of Potato PlentyThe potato is a versatile vegetable—baked, roasted, fried, mashed—it can bring something to just about any menu. But, how exactly do these tasty tubers end up on our tables? We’ll give you a crash course in potato science, including how potatoes are grown (hint: not from seeds!) and what scientists look for when they develop new potato varieties.SciFri producer Kathleen Davis talks with Dr. Rhett Spear, assistant professor in the Plant Sciences Department at the University of Idaho. Adding Marbling To Fake Meat For That Extra-Realistic BitePlant-based meat products have evolved over the past few decades. You can find them in many forms, like sausages, deli meats, and faux chicken nuggets. During the holiday season, no plant-based meat is more famous than the Tofurky Roast, a round imitation turkey.Despite improvements in flavor for plant-based meat products, there are still lots of challenges to getting fake meats to mimic their real counterparts. One tough one is textural: instilling a marbling effect. This is the effect of irregular fat deposits, which occur naturally in animal meat.Plant-based meat has a uniform texture by design. Because each product is processed to be a certain way, the randomness and irregularity of fat pockets is taken out of the equation. But some food scientists are working on adding more of this meaty texture to plant-based meat.Joining guest host Kathleen Davis to discuss the challenges and possibilities for the next stage of plant-based meat is Dr. David Julian McClements, distinguished professor in food science at the University of Massachusetts Amherst.Transcripts for each segment will be available after the show airs on sciencefriday.com.
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A Nutritionist Clarifies Some Common Health Claims
We recently asked our listeners which dubious health claims they’ve been seeing in their social media feeds or being circulated by friends and family. Unsurprisingly, we received a ton of questions about nutrition, including: Is seed oil bad for you? Does apple cider vinegar really lower blood sugar? What is the difference between processed and ultraprocessed foods? To answer those questions and more, SciFri producer Kathleen Davis talks with RDN Jessica Clifford, a nutrition specialist at Department of Food Science and Human Nutrition at Colorado State University. Transcripts for each segment will be available after the show airs on sciencefriday.com.
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Restoring Drinking Water After Hurricane Helene | Oyster Shell Reefs And Sea Level Rise
Fifty-three days after Hurricane Helene, residents of Asheville can safely drink their tap water without boiling it. Why did it take so long? And, tribes’ historic lands on the Gulf Coast are being lost to the sea. To slow it down, one tribe has turned to oyster shells.The Struggle To Restore Drinking Water After Hurricane HeleneWhen Hurricane Helene barrelled through the southeastern US in September, it dumped an estimated 40 trillion gallons of water on the region. That resulted in immense flooding that destroyed roads, buildings, power lines, and other infrastructure.And it also impacted the region’s potable water supply. For weeks, residents in Asheville, North Carolina, didn’t have access to clean drinking water because the extensive flooding washed large amounts of sediment into the local reservoir. As of Monday, limited access to potable water was restored, marking the first time in 53 days that local residents didn’t have to boil tap water to drink it.Before that access was restored, we heard from listeners Sarah and Alison in Asheville who had their own questions about the water quality in their city, and the science behind sediment issues in a local reservoir.Guest host and SciFri producer Kathleen Davis is joined by Dr. Sarah Ledford, associate professor of geosciences at Georgia State University, to figure out why it can take so long for cities to clean their potable water after a storm like this and what other regions expect from the aftermath of future extreme weather.Using Oyster Shell Reefs To Counter Sea Level Rise In LouisianaOn a hot Friday morning, the sun beat down on volunteers gathered at the edge of the water in southern Plaquemines Parish. They passed heavy sacks of oyster shells to each other down a line. The volunteers loaded the shells onto boats to use them for building an oyster reef to help slow land loss in Grand Bayou Indian Village.“The oyster reef is a living thing. Baby oysters are going to attach to it. It’s going to grow. It’s going to become bigger,” said James Karst with the Coalition for Coastal Louisiana, the organization that built the reef. “But when the sea level rises, because oysters are growing on it, it will grow vertically as well, so it will continue to add protection.”Louisiana’s land loss is an existential crisis for many of the tribes who live along the coast. Grand Bayou Indian Village, a small community, home to the Atakapa-Ishak/Chawasha tribe, is watching its lands wash away. Nearly 1,000 people lived in the village in the 1940s, but now there are only about a dozen homes raised on stilts right along the edge of the bayou. Boats are the only way to get around.“You can look at the GPS and it will indicate a different color for where land is,” said Karst. “You’ll be looking at this on the screen, then you’ll look up and there is no land there. It’s just open water.”Volunteers built the reef by stacking bags of recycled oyster shells in the water, up and down the shoreline. The shells came from restaurants in New Orleans. The coalition recently expanded its oyster recycling services to Baton Rouge.Read the full story at sciencefriday.com.Transcripts for each segment will be available after the show airs on sciencefriday.com.
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